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Jan 25, - As you age, the tissue and structure of your breasts begin to change. ovulation and menstruation, and after which she can no longer have children. A woman is officially in menopause once she has not had a period for May 13, - In the hormone's absence, the breasts shrink because the ducts and mammary glands shrink, and the breasts become less firm and lose their shape. You may notice a sagging of the breasts in older women. But hormone replacement therapy won't stop sagging in breasts that were sagging before you started taking the drug.